The MSR1 Antibody (C-term) from MyBioSource.com is a Rabbit Polyclonal antibody to CD204, MSR1, Scara1, and SR-AII. This antibody recognizes Human, and Mouse antigen. The MSR1 Antibody (C-term) has been validated for the following applications: ELISA, and Western Blot.
Description
This gene encodes the class A macrophage scavenger
receptors, which include three different types (1, 2, 3) generated
by alternative splicing of this gene. These receptors or isoforms
are macrophage-specific trimeric integral membrane glycoproteins
and have been implicated in many macrophage-associated
physiological and pathological processes including atherosclerosis,
Alzheimer's disease, and host defense. The isoforms type 1 and type
2 are functional receptors and are able to mediate the endocytosis
of modified low density lipoproteins (LDLs). The isoform type 3
does not internalize modified LDL (acetyl-LDL) despite having the
domain shown to mediate this function in the types 1 and 2
isoforms. It has an altered intracellular processing and is trapped
within the endoplasmic reticulum, making it unable to perform
endocytosis. The isoform type 3 can inhibit the function of
isoforms type 1 and type 2 when co-expressed, indicating a dominant
negative effect and suggesting a mechanism for regulation of
scavenger receptor activity in macrophages